Key result
Mild chronic renal failure in patients undergoing coronary artery bypass grafting was associated with the overexpression of 97 aortic transcripts, particularly LUM and ODC1, compared to controls.
Population
9 patients with coronary artery disease scheduled for a coronary artery bypass graft, with or without mild…
Comparison
Mild chronic renal failure (CRF) vs No chronic renal failure (controls)
Design
Cross-sectional
Authors
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Mild CRF-linked aortic transcripts warrant no CABG practice change; leaves open mechanistic roles in cardiorenal risk.
Observational (n=9)
Patients with mild chronic renal failure undergoing CABG exhibit a specific aortic gene expression profile characterized by the upregulation of genes involved in collagen fibrillogenesis and smooth muscle cell proliferation, such as LUM and ODC1.
Fassot et al. (2008) conducted an observational in Coronary artery disease with or without chronic renal failure (n=9). Chronic renal failure vs. Without chronic renal failure was evaluated on Differentially expressed aortic transcripts. Mild chronic renal failure in patients undergoing coronary artery bypass grafting was associated with the overexpression of 97 aortic transcripts, particularly LUM and ODC1, compared to controls.
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