What is the clinical evidence from this study?

Study design: Other. Population: Aortic stiffness (n=18). Intervention: Vitamin D3-nicotine (VDN) treatment vs. Control. Primary outcome: Left ventricular weight/body weight ratio (g/kg) (p=0.0397).

What question did this study set out to answer?

To evaluate the cardiac structural and functional consequences of prolonged 3-month exposure to isolated aortic stiffness in a rat model of aortic elastocalcinosis.

July 1, 1999Hypertension

Cardiac Consequences of Prolonged Exposure to an Isolated Increase in Aortic Stiffness

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Key result

Prolonged 3-month exposure to increased aortic stiffness in rats induced LV hypertrophy (LV weight/body weight ratio 1.73 vs 1.54 g/kg; P=0.0397) and fibrosis, while maintaining LV performance.

Population

18 awake rats (8 control and 10 VDN model of aortic elastocalcinosis induced by vitamin D3-nicotine treatment)

Comparison

3 months exposure to increased aortic stiffness… vs Control rats without VDN treatment

Design

Preclinical

Follow-up

3 months

Authors

ILIsabelle LartaudUniversité de Lorraine ALAnne‐Marie LompréHeart Failure / Cardiomyopathy PKPascal KiefferCentre de Recherche en Mathématiques de la Décision

Discussion

Member takes

Implication

Rat model links aortic stiffness to LV remodeling; hypothesis-generating and leaves human translation open.

Key Points

To evaluate the cardiac structural and functional consequences of prolonged 3-month exposure to isolated aortic stiffness in a rat model of aortic elastocalcinosis.
Studied 18 awake rats (8 controls and 10 vitamin D3-nicotine [VDN]-treated rats) 3 months after induction of aortic stiffness.
Measured aortic characteristic impedance and stroke volume via an electromagnetic probe at baseline and during acute volume overload.
Assessed left ventricular (LV) weight-to-body weight ratio, LV collagen content, and alpha/beta myosin heavy chain (MHC) isoform distribution.
Aortic characteristic impedance increased in VDN rats (50 ± 8 vs 32 ± 2 × 10³ dyne·s/cm⁵; P=0.0248), while stroke volume was maintained at baseline (211 ± 13 vs 223 ± 18 µL) and during volume overload (338 ± 15 vs 378 ± 14 µL).
Rats developed LV hypertrophy with increased LV weight-to-body weight ratio (1.73 ± 0.05 vs 1.54 ± 0.07 g/kg; P=0.0397) and higher LV collagen content (52 ± 4 vs 31 ± 4 µg/g dry wt; P=0.0192).
A significant shift occurred from alpha-MHC (69 ± 3% vs 82 ± 2%; P=0.0056) to beta-MHC (31 ± 3% vs 18 ± 2%; P=0.0056) in stiffened animals.

Structured PICO

Population

18 awake rats (8 control and 10 VDN model of aortic elastocalcinosis induced by vitamin D3-nicotine treatment)

Intervention

3 months exposure to increased aortic stiffness induced by vitamin D3-nicotine (VDN) treatment

Comparator

Control rats without VDN treatment

Outcome

Cardiac function (stroke volume at baseline and after acute volume overload) and structure (LV weight/body weight ratio, collagen, and myosin heavy chain contents)surrogate

Main Result

Absolute Event Rate: 1.73% vs 1.54%

p-value: p=0.0397

Prolonged exposure to increased aortic stiffness in a rat model induces structural adaptation including LV hypertrophy and interstitial fibrosis, which maintains LV performance.

Cite This Study

Lartaud et al. (1999) studied Aortic stiffness (n=18). Vitamin D3-nicotine (VDN) treatment vs. Control was evaluated on Left ventricular weight/body weight ratio (g/kg) (p=0.0397). Prolonged 3-month exposure to increased aortic stiffness in rats induced LV hypertrophy (LV weight/body weight ratio 1.73 vs 1.54 g/kg; P=0.0397) and fibrosis, while maintaining LV performance.

synapsesocial.com/papers/6a0d6ddfcae7912d2fa4ff51 https://doi.org/10.1161/01.hyp.34.1.63

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Cardiac Consequences of Prolonged Exposure to an Isolated Increase in Aortic Stiffness

Discussion

Member takes

Implication

Key Points

Structured PICO

Main Result

Cite This Study

Cardiac Consequences of Prolonged Exposure to an Isolated Increase in Aortic Stiffness

Discussion

Member takes

Implication

Key Points

Structured PICO

Main Result

Cite This Study

Also Consider

Also Consider