Why the study?
Does perindopril reduce cardiac mass and aortic stiffness in a rat model of isolated systolic hypertension?
Population
Rat model of isolated systolic hypertension produced by calcium overload of elastic arteries after vitamin…
Comparison
Perindopril 1 mg/kg per day PO chronically vs No perindopril treatment
Design
Preclinical
Authors
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ACE inhibition may reduce cardiac mass and aortic stiffness in experimental isolated systolic hypertension; hypothesis-generating for clinical translation.
Does perindopril reduce cardiac mass and aortic stiffness in a rat model of isolated systolic hypertension?
In a rat model of isolated systolic hypertension, ACE inhibition with perindopril reversed increases in cardiac mass and aortic stiffness, demonstrating a link between arterial elasticity and cardiac mass.
Tatchum‐Talom et al. (1995) studied this question.
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