Key result
Hemodialysis independently advanced carotid atherosclerosis and arteriosclerosis, increased left ventricular mass index, and caused cardiac dysfunction, which were further accelerated by hypertension.
Why the study?
Do hemodialysis and hypertension affect the structure and function of the carotid artery and left ventricle?
Observational (n=153)
Do hemodialysis and hypertension affect the structure and function of the carotid artery and left ventricle?
Hemodialysis and hypertension independently and synergistically contribute to adverse structural and functional changes in the carotid artery and left ventricle.
Answers are grounded in this paper and cite their sources.
Supports closer CV surveillance in hemodialysis patients with hypertension; hypothesis-generating for synergistic effects on carotid and LV remodeling.
Hemodialysis patients frequently show associated hypertension, which can lead to a number of cardiovascular complications. The aim of this study was to assess the effects of hypertension on the structure and function of the carotid artery and left ventricle (LV) in hemodialysis patients. In addition, we investigated the contribution of hemodialysis and other risk factors. Fifty-two hemodialysis patients, 71 hypertensive patients (HT group) and 30 normotensive subjects (NT group) were included in this study. Hemodialysis patients were divided into two groups: 35 patients with hypertension (HDHT group), and 17 patients without hypertension (HDNT group). We measured intima-media thickness (IMT), plaque score, end-diastolic diameter, and stiffness index beta of the carotid artery by ultrasonography, and LV mass index (LVMi), endocardial fractional shortening (FS), and midwall FS (MWS) by echocardiography. A multiple stepwise regression analysis including hemodialysis, hypertension, diabetes mellitus, and other risk factors was also performed. IMT was significantly higher in the HT and HDHT groups than in the NT group. Plaque score and diameter of the carotid artery were higher in the HDHT group than in the other three groups. The stiffness index beta was higher in the HDHT group than in the non-hemodialysis groups. In multivariate analysis, IMT was independently correlated with age and hypertension. Plaque score and stiffness index beta were independently associated with age, hypertension, and hemodialysis. LVMi was higher in HT and hemodialysis-patients groups than in the NT group. Hypertension and hemodialysis were strong and independent predictors of LVMi. FS showed no significant differences among the four groups, but MWS was significantly lower among the hemodialysis patients than in the NT group. MWS was independently correlated with hemodialysis and diabetes. In conclusion, hemodialysis per se advanced both atherosclerosis and arteriosclerosis of the carotid artery. Moreover, it increased LVMi and caused cardiac dysfunction. Associated hypertension might thus accelerate the progression of atherosclerosis and arteriosclerosis of the carotid artery and the increase of LVMi.
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Kawada et al. (2001) conducted an observational in Hemodialysis and hypertension (n=153). Hemodialysis and hypertension vs. Normotensive subjects and non-hemodialysis hypertensive patients was evaluated on Structure and function of the carotid artery (IMT, plaque score, diameter, stiffness index beta) and left ventricle (LVMi, FS, MWS). Hemodialysis independently advanced carotid atherosclerosis and arteriosclerosis, increased left ventricular mass index, and caused cardiac dysfunction, which were further accelerated by hypertension.
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