Key result
Hemodialysis is linked to advanced atherosclerosis, higher carotid IMT, and greater plaque prevalence versus controls.
Why the study?
Do hemodialysis patients have increased carotid intima-media thickness and plaque prevalence compared to normal controls?
Case-Control (n=56)
Do hemodialysis patients have increased carotid intima-media thickness and plaque prevalence compared to normal controls?
Hemodialysis patients exhibit advanced atherosclerosis in the carotid arteries compared to age- and sex-matched normal subjects, as evidenced by increased IMT and plaque prevalence.
May support intensified vascular monitoring in hemodialysis; leaves open whether screening alters outcomes.
Atherosclerosis is accelerated in hemodialysis patients. Using B-mode ultrasonography, we compared intima-media thickness (IMT) and the prevalence of plaques in the common carotid and internal carotid arteries in 28 randomly selected hemodialysis patients with that in 28 age- and sex-matched normal controls. The IMT values of the common carotid and internal carotid arteries were higher in hemodialysis patients than in controls with more hemodialysis patients having plaques. In hemodialysis patients, there was a relationship between age and IMT in the common carotid arteries, in the area of bifurcation, and in the internal carotid arteries. We found no relationship between IMT and atherosclerotic risk factors or duration of hemodialysis treatment. IMT at all sites correlated with the number of plaques. Age was the only significant determinant for number of plaques. The results indicate that hemodialysis patients showed advanced atherosclerosis in the carotid arteries compared with age- and sex-matched normal subjects.
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Radovan Hojs (2000) conducted a case-control in Hemodialysis (n=56). Hemodialysis vs. Age- and sex-matched normal controls was evaluated on Intima-media thickness (IMT) and prevalence of plaques in the common and internal carotid arteries. Hemodialysis patients exhibited advanced atherosclerosis, with higher carotid intima-media thickness and a greater prevalence of plaques compared with age- and sex-matched normal controls.
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