Key result
Dialysis links to higher carotid IMT versus controls, with peritoneal dialysis exceeding hemodialysis.
Why the study?
Atherosclerosis is a major risk factor for cardiovascular morbidity and mortality in dialysis patients, but the relationship between dialysis modalities and atherosclerotic changes is not fully understood.
Does the modality of dialysis affect carotid intima media thickness in patients without clinical cardiovascular disease?
Cross-Sectional (n=65)
Does the modality of dialysis affect carotid intima media thickness in patients without clinical cardiovascular disease?
Carotid intima media thickness is significantly increased in dialysis patients, particularly those on peritoneal dialysis, with distinct risk factor profiles driving atherosclerosis in each modality.
Answers are grounded in this paper and cite their sources.
Carotid IMT screening may detect subclinical atherosclerosis in asymptomatic dialysis patients; leaves open its prognostic utility.
INTRODUCTION: Atherosclerosis is a major risk factor for increased cardiovascular morbidity and mortality in dialysis patients. First clinical symptoms are usually associated with initial atherosclerotic changes of blood vessels. The aim of this study was ultrasound evaluation of intima media thickness (IMT) of carotid arteries in dialysis patients and its correlation with certain risk factors. PATIENTS AND METHODS: IMT was measured in 45 dialysis patients with no signs of cardiovascular diseases: 15 continuous ambulatory peritoneal dialysis (CAPD) patients, 30 hemodialysis (HD) patients and in 20 healthy controls. IMT was correlated with certain risk factors for atherosclerosis (general parameters--age, gender, duration of dialysis, cause of renal diseases, parameters of nutrition, parameters of calcium and phosphorus metabolism, lipid parameters, blood pressure and smoking). RESULTS: The mean carotid artery IMT was significantly higher in dialysis patients than in the control group (p < 0.05). In addition, the mean IMT was statistically significantly higher in PD than in HD patients (p < 0.05). In CAPD patients there was a significant correlation between IMT and total and LDL cholesterol. In the second group (HD patients) IMT significantly correlated with diastolic blood pressure, BMI and smoking. CONCLUSION: Although atherosclerotic cardiovascular disease may not manifest in dialysis patients, IMT of carotid arteries significantly increases. Major risk factors affecting IMT are lipid disturbances in patients on peritoneal dialysis and hypertension, obesity and smoking in HD patients.
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Damjanović et al. (2003) conducted a cross-sectional in Dialysis (n=65). Dialysis vs. Healthy controls was evaluated on Intima media thickness (IMT) of carotid arteries (p=< 0.05). Carotid artery intima media thickness was significantly higher in dialysis patients compared to healthy controls (p < 0.05), and higher in peritoneal dialysis than hemodialysis patients (p < 0.05).
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