Key result
Dialysis is linked to higher carotid IMT versus healthy controls, correlating with lipids, BMI, and BP.
Why the study?
Atherosclerosis is a significant risk factor for cardiovascular morbidity and mortality in dialysis patients, and its relationship with proposed risk factors needs evaluation.
Is carotid intima media thickness increased in dialysis patients compared to healthy controls, and does it correlate with cardiovascular risk factors?
Cross-Sectional (n=65)
Is carotid intima media thickness increased in dialysis patients compared to healthy controls, and does it correlate with cardiovascular risk factors?
Carotid intima media thickness is significantly increased in dialysis patients and correlates with traditional risk factors like lipid disturbances, obesity, and hypertension, highlighting its potential as an early marker of atherosclerosis.
Answers are grounded in this paper and cite their sources.
Carotid IMT assessment may flag atherosclerosis in dialysis patients; leaves open its prognostic value and clinical utility.
Atherosclerosis is significant risk factor for cardiovascular morbidity and mortality in dialysis patients. Aim of the study was ultrasound evaluation of intima media thickness on carotid arteries (as a marker of atherosclerosis), in dialysis patients and its correlation with proposed risk factors. Intima media thickness was measured in 45 dialysis patients with no signs of cardiovascular diseases (15 on peritoneal dialysis, group I, 30 on hemodialysis, group II) and 20 healthy controls. The mean carotid artery intima media thickness was significantly higher in dialysis patients than in control group. According to intima media thickness, dialysis patients were divided in group A (patient with intima media thickness less or equal 0.720 mm) and group B (intima media thickness higher then 0.720 mm). Intima media thickness in bout group was correlated with proposed risk factors. In group A there was not significant correlation of intima media thickness with risk factors. In group B significant correlation have been found between intima media thickness and LDL, VLDL cholesterol, body mass index and systolic, diastolic and mean blood pressure. Although atherosclerosis was not the only cause for cardiovascular morbidity and mortality, it has a dominant role in dialysis patients. Augmented intima media thickness could be early marker of atherosclerosis. The risk factors of great influence on intima media thickness are lipid disturbances, obesity and hypertension.
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Damjanović et al. (2003) conducted a cross-sectional in End-stage renal disease on dialysis (n=65). Dialysis vs. Healthy controls was evaluated on Carotid artery intima media thickness. Dialysis patients had significantly higher carotid intima media thickness than healthy controls, and IMT >0.720 mm significantly correlated with LDL, VLDL, BMI, and blood pressure.
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