Key result
Maintenance hemodialysis is associated with higher CA-IMT versus healthy controls, driven by phosphate, prealbumin, and SBP.
Why the study?
What are the independent risk factors associated with increased carotid intima-media thickness in maintenance hemodialysis patients?
Cross-Sectional (n=105)
What are the independent risk factors associated with increased carotid intima-media thickness in maintenance hemodialysis patients?
In maintenance hemodialysis patients, high serum phosphate, low serum prealbumin, and high systolic blood pressure are independently associated with increased carotid intima-media thickness, a marker of arteriosclerosis.
CA-IMT may mark vascular risk in MHD patients; cross-sectional data leave causality and clinical utility open.
BACKGROUND: To investigate the relationship between the intima-media thickness of the carotid artery (CA-IMT) and its major risk factors in maintenance hemodialysis (MHD) patients. METHODS: Seventy-five MHD patients and 30 healthy volunteers were enrolled. The MHD patients were divided into 3 subgroups according to their CA-IMT value. RESULTS: CA-IMT values in the MHD group were significantly higher than those in the control group. The differences in age, systolic blood pressure (SBP), and levels of serum albumin, prealbumin, cholesterol and serum phosphate between the increased IMT group and the normal IMT group were significant. SBP and serum phosphate levels were also greater in the abnormal IMT group than those in the normal IMT group. Significant relationships were found between CA-IMT and age, SBP, and serum levels of phosphate, albumin and prealbumin. In multiple regression analysis, a high serum phosphate level, low serum prealbumin level and high SBP were significant independent risk factors of increased CA-IMT. CONCLUSIONS: CA-IMT was increased dramatically in MHD patients. A high serum phosphate level, low serum prealbumin level and high SBP may be associated with advanced arteriosclerosis.
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Kuang et al. (2009) conducted a cross-sectional in Maintenance hemodialysis (n=105). Maintenance hemodialysis vs. Healthy volunteers was evaluated on Carotid artery intima-media thickness (CA-IMT). Maintenance hemodialysis was associated with significantly higher carotid artery intima-media thickness compared to healthy controls, with high phosphate, low prealbumin, and high SBP as risk factors.
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