Key result
Static hindlimb contraction in decerebrate rats increased mean arterial pressure by 23 +/- 2 mmHg, contrasting with a 17 +/- 3 mmHg decrease in intact anesthetized rats.
Population
Sprague-Dawley rats (300-400 g), n=20 (10 intact halothane-anaesthetized, 10 decerebrate)
Comparison
Static hindlimb contractions and passive stretch vs Intact halothane-anaesthetized rats
Design
Preclinical
Authors
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Decerebrate rat model reliably elicits exercise pressor reflex; leaves open translation to conscious humans.
Absolute Event Rate: 23% vs -17%
The decerebrate rat preparation is a reliable model for studying the exercise pressor reflex, avoiding the suppressive cardiovascular effects of anesthesia.
Smith et al. (2001) studied Exercise pressor reflex (n=20). Static hindlimb contraction and passive stretch vs. Intact halothane-anaesthetized animals was evaluated on Change in mean arterial pressure (MAP) during contraction. Static hindlimb contraction in decerebrate rats increased mean arterial pressure by 23 +/- 2 mmHg, contrasting with a 17 +/- 3 mmHg decrease in intact anesthetized rats.
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