Key result
Activation of the exercise pressor reflex via static contraction or passive stretch induced renal cortical vasoconstriction through sympathetic activation in rats.
Why the study?
Does activation of the exercise pressor reflex alter renal sympathetic nerve activity and renal cortical vascular conductance in rats?
Population
Mid-collicular decerebrate rats
Comparison
30 s of static contraction of the left triceps… vs Baseline and renal denervation
Design
Preclinical
Follow-up
30 seconds
Authors
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Should not yet change practice; leaves open translation of mechanoreflex-driven renal sympathetic activation to human disease.
Does activation of the exercise pressor reflex alter renal sympathetic nerve activity and renal cortical vascular conductance in rats?
p-value: p=<0.05
Both the exercise pressor reflex and its mechanically sensitive component, the muscle mechanoreflex, induce renal cortical vasoconstriction through sympathetic activation in rats.
Koba et al. (2005) studied this question. Activation of the exercise pressor reflex (static contraction or passive stretch) vs. Baseline was evaluated on Mean arterial pressure, heart rate, renal sympathetic nerve activity, and renal cortical vascular conductance (p=<0.05). Activation of the exercise pressor reflex via static contraction or passive stretch induced renal cortical vasoconstriction through sympathetic activation in rats.
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