CineECG detects abnormal electrical activity in the 12-lead ECG of preclinical plakophilin-2 variant carriers

Figures

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  Figure 1. Flowchart. After 2:1 age- and sex-matching the preclinical Plakophilin-2 (likely) pathogenic variant (PKP2-(L)PV) carriers to control subjects, the ECGs were transformed to CineECG trajectories. ECGs of control subjects were used to create a normal distribution of trajectories. The median of this normal distribution is shown entirely in white. An example of a trajectory of a PKP2-(L)PV carrier is shown in color (start depolarization = white, end repolarization = blue). The lower row demonstrates the direction of the trajectory of the PKP2-(L)PV carrier (green line) and normal distribution (orange) as seen from 3 different axes.ECG = electrocardiogram.

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  Figure 2. Depolarization and repolarization trajectories. Trajectories of 4 Plakophilin-2 (likely) pathogenic variant carriers for depolarization (white through red) and repolarization (yellow until blue). The median trajectory of the normal distribution is shown in white. Examples are shown of a trajectory that was normal for both depolarization and repolarization (upper row), abnormal depolarization and normal repolarization (second row), normal depolarization and abnormal repolarization (third row), and both abnormal depolarization and repolarization (fourth row).