Why the study?
Multiple pacing-induced and myocardial conditions cause or worsen mitral regurgitation in patients with right ventricular apical pacing, making etiological determination difficult for guiding cardiac resynchronization therapy.
Comprehensive echocardiographic evaluation is essential to determine the etiology of mitral regurgitation in patients with right ventricular apical pacing and to identify candidates for cardiac resynchronization therapy.
The presence of mitral regurgitation (MR) in patients with right ventricular apical pacing can be the result of multiple phenomena. On the one hand, this stimulation causes an asynchronous activation of the left ventricle (LV) and the papillary muscles, leading to a deterioration of the LV ejection fraction and causing an inadequate closure of the valve apparatus. However, there is a wide heterogeneity of ischemic and non-ischemic myocardial conditions that can coexist with mechanical alteration of the LV and the mitral valve leading to or worsening MR in these patients, which can make the etiological determination of valvular regurgitation difficult. Transthoracic echocardiography study allows comprehensive evaluation of mitral valve regurgitation and ventricular function parameters and mechanical asynchrony as a result of artificial pacing. The comprehensive study of these phenomena is relevant in clinical decision-making to define those patients who benefit from cardiac resynchronization therapy to alleviate symptomatic MR.
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Azanza et al. (2021) studied this question.
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