Key result
Apolipoprotein AI-derived amyloid was detected in 100% of calcific aortic valves versus 0% of controls, and was shown to promote mineralization by increasing apoptosis of interstitial cells.
Population
70 explanted calcific aortic valve disease valves and 15 control non-calcified aortic valves, plus isolated…
Comparison
Histological and immunohistochemical analysis… vs 15 control non-calcified aortic valves.
Design
Preclinical
Authors
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Apolipoprotein A-I amyloid is hypothesis-generating in calcific aortic stenosis; human studies needed before any clinical relevance or targeting.
Case-Control (n=85)
Absolute Event Rate: 100% vs 0%
Apolipoprotein A-I is a major component of amyloid in calcific aortic valves, which promotes mineralization by inducing apoptosis of valvular interstitial cells.
Audet et al. (2012) conducted a case-control in Calcific aortic valve disease (CAVD) (n=85). Apolipoprotein AI-derived amyloid was detected in 100% of calcific aortic valves versus 0% of controls, and was shown to promote mineralization by increasing apoptosis of interstitial cells.
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