Why the study?
Does low-dose aspirin prevent pregnancy-induced hypertension in pregnant women?
Population
394 pregnant women from 6 controlled trials
Comparison
Low-dose aspirin during the second and third… vs Control group
Design
Meta-analysis
Key result
Low-dose aspirin reduced the risk of pregnancy-induced hypertension (RR 0.35; 95% CI 0.22-0.55) and severe low birth weight (RR 0.56; 95% CI 0.36-0.88) among high-risk pregnant women.
Authors
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Supports low-dose aspirin in high-risk pregnancies; confirms benefit across aggregated trials.
Meta-Analysis (n=394)
Does low-dose aspirin prevent pregnancy-induced hypertension in pregnant women?
Effect estimate: RR 0.35 (95% CI 0.22 to 0.55)
Low-dose aspirin during the second and third trimesters significantly reduces the risk of pregnancy-induced hypertension and severe low birth weight.
Thomas F. Imperiale (1991) conducted a meta-analysis in Pregnancy-induced hypertension (n=394). Aspirin vs. Control was evaluated on Pregnancy-induced hypertension (PIH) (RR 0.35, 95% CI 0.22 to 0.55). Low-dose aspirin reduced the risk of pregnancy-induced hypertension (RR 0.35; 95% CI 0.22-0.55) and severe low birth weight (RR 0.56; 95% CI 0.36-0.88) among high-risk pregnant women.