What is the clinical evidence from this study?

Population: Left ventricular myocardial function assessment (n=10). Intervention: 3-Dimensional Speckle Tracking Imaging (3D-STI) vs. Sonomicrometry. Primary outcome: Correlation of segmental longitudinal (LS), radial (RS), and circumferential strain (CS) measurements (r=0.89 (LS), r=0.84 (RS), r=0.90 (CS), p=<0.001).

What question did this study set out to answer?

To validate left ventricular regional myocardial strain measurements obtained from three-dimensional speckle tracking imaging against gold-standard sonomicrometry.

September 13, 2009Circulation Cardiovascular ImagingOpen Access

Validation of 3-Dimensional Speckle Tracking Imaging to Quantify Regional Myocardial Deformation

Q: What are the key findings of this study?

3-Dimensional Speckle Tracking Imaging accurately estimated LV regional longitudinal (r=0.89), radial (r=0.84), and circumferential (r=0.90) strain compared to sonomicrometry (P<0.001).

Q: What question did this study set out to answer?

To validate left ventricular regional myocardial strain measurements obtained from three-dimensional speckle tracking imaging against gold-standard sonomicrometry.

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Key result

3-Dimensional Speckle Tracking Imaging accurately estimated LV regional longitudinal (r=0.89), radial (r=0.84), and circumferential (r=0.90) strain compared to sonomicrometry (P<0.001).

Why the study?

Does 3-dimensional speckle tracking imaging accurately quantify regional myocardial deformation compared to sonomicrometry in an animal model?

Population

10 anesthetized sheep with sonomicrometry crystals implanted on the endocardium and epicardium at the LV…

Comparison

Three-dimensional speckle tracking imaging to… vs Sonomicrometry (reference standard)

Design

Preclinical

Authors

YSYoshihiro SeoUniversity of California, San Francisco TITomoko IshizuCardiac Imaging YEYoshiharu EnomotoIbaraki Prefectural Central Hospital

Discussion

Member takes

Implication

Supports 3D-STI regional strain assessment in animals; leaves open human validation before clinical use.

Key Points

To validate left ventricular regional myocardial strain measurements obtained from three-dimensional speckle tracking imaging against gold-standard sonomicrometry.
Sonomicrometry crystals were surgically implanted along the endocardium and epicardium of the basal, mid, and apical left ventricular walls in 10 anesthetized sheep.
Three-dimensional speckle tracking datasets were captured (~30 frames/s) and compared to sonomicrometry at baseline, during dobutamine and propranolol infusions, and during acute coronary artery occlusion.
Overall strain measurements demonstrated strong agreement with sonomicrometry across longitudinal (r=0.89, P<0.001; n=136), radial (r=0.84, P<0.001; n=175), and circumferential strain (r=0.90, P<0.001; n=108).
Segmental evaluations consistently maintained significant correlations for all directional components (longitudinal r=0.65 to 0.68, radial r=0.59 to 0.70, circumferential r=0.71 to 0.78; all P<0.001).

Structured PICO

Does 3-dimensional speckle tracking imaging accurately quantify regional myocardial deformation compared to sonomicrometry in an animal model?

Population

10 anesthetized sheep with sonomicrometry crystals implanted on the endocardium and epicardium at the LV basal, mid, and apical anterior and lateral walls

Intervention

Three-dimensional speckle tracking imaging (3D-STI) to measure segmental longitudinal (LS), radial (RS), and circumferential strain (CS) at baseline, during pharmacological stress (dobutamine and propranolol infusion), and acute myocardial ischemia

Comparator

Sonomicrometry (reference standard)

Outcome

Correlation between strain measurements by 3D-STI and sonomicrometrysurrogate

Main Result

Effect estimate: r=0.89 (LS), r=0.84 (RS), r=0.90 (CS)

p-value: p=<0.001

3D-STI is a reliable tool for estimating LV regional circumferential, longitudinal, and radial strain components, showing good correlation with sonomicrometry in an animal model.

Cite This Study

Seo et al. (2009) studied Left ventricular myocardial function assessment (n=10). 3-Dimensional Speckle Tracking Imaging (3D-STI) vs. Sonomicrometry was evaluated on Correlation of segmental longitudinal (LS), radial (RS), and circumferential strain (CS) measurements (r=0.89 (LS), r=0.84 (RS), r=0.90 (CS), p=<0.001). 3-Dimensional Speckle Tracking Imaging accurately estimated LV regional longitudinal (r=0.89), radial (r=0.84), and circumferential (r=0.90) strain compared to sonomicrometry (P<0.001).

synapsesocial.com/papers/6a0d947768ddba849a09c91c https://doi.org/10.1161/circimaging.109.858480

Topics

Echocardiography

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Validation of 3-Dimensional Speckle Tracking Imaging to Quantify Regional Myocardial Deformation

Discussion

Member takes

Implication

Key Points

Structured PICO

Main Result

Cite This Study

Topics

Validation of 3-Dimensional Speckle Tracking Imaging to Quantify Regional Myocardial Deformation

Discussion

Member takes

Implication

Key Points

Structured PICO

Main Result

Cite This Study

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Topics

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