Speckle tracking echocardiography showed good correlation and agreement with MRI tagging for measuring left ventricular long-axis strain in human subjects (r = 0.87, p < 0.001).
Observational
Does speckle tracking echocardiography provide accurate measurements of regional myocardial strain compared to sonomicrometry and MRI tagging?
Speckle tracking echocardiography provides accurate, angle-independent measurements of left ventricular strain, correlating well with established reference methods like sonomicrometry and MRI tagging.
Effect estimate: r = 0.87 (95% CI -9.1% to 8.0%)
p-value: p=<0.001
OBJECTIVES: The aim of this study was to validate speckle tracking echocardiography (STE) as a method for angle-independent measurement of regional myocardial strain, using sonomicrometry and magnetic resonance imaging (MRI) tagging as reference methods. BACKGROUND: Tissue Doppler imaging allows non-invasive measurement of myocardial strain in the left ventricle (LV), but is limited by angle dependency. METHODS: Strain measurements with STE were obtained by a custom-made program that allowed tracking of two-dimensional motion of speckle patterns in a B-mode image. In anesthetized dogs, we compared LV long- and short-axis measurements by STE to sonomicrometry during preload changes and regional myocardial ischemia. Measurements in the two orthogonal axes were obtained simultaneously in a single imaging plane. In human subjects, long-axis strain by STE and MRI tagging were compared in multiple segments of the LV. RESULTS: In the experimental study there was good correlation and agreement between STE and sonomicrometry for systolic strain in the long axis (r = 0.90, p < 0.001; 95% limits of agreement -4.4% to 5.0%) and systolic shortening in the short axis (r = 0.79, p < 0.001; -5.6% to 5.1%). In the clinical study, 80% of the segments could be analyzed, and correlation and agreement between STE and MRI tagging were good (r = 0.87, p < 0.001; -9.1% to 8.0%). CONCLUSIONS: Speckle tracking echocardiography provides accurate and angle-independent measurements of LV dimensions and strains and has potential to become a clinical bedside tool for quantifying myocardial strain.
Amundsen et al. (Fri,) reported a observational. Speckle tracking echocardiography (STE) vs. Sonomicrometry and MRI tagging was evaluated on Correlation and agreement of myocardial strain measurements (r = 0.87, 95% CI -9.1% to 8.0%, p=<0.001). Speckle tracking echocardiography showed good correlation and agreement with MRI tagging for measuring left ventricular long-axis strain in human subjects (r = 0.87, p < 0.001).