Key result
In prehypertensive spontaneously hypertensive rats, renal oxidative stress appears before inflammation as a primary abnormality, and antioxidant treatment reduces renal inflammation.
Why the study?
Does oxidative stress precede renal inflammation in spontaneously hypertensive rats?
Does oxidative stress precede renal inflammation in spontaneously hypertensive rats?
Oxidative stress appears to precede inflammation as a primary renal abnormality in the development of hypertension in spontaneously hypertensive rats.
Hypothesis-generating for early renal oxidative stress targeting in hypertension models; leaves open clinical translation and human trials.
The present study was undertaken to identify whether inflammation or oxidative stress is the primary abnormality in the kidney in spontaneously hypertensive rats (SHR). Renal inflammation and oxidative stress were evaluated in 2- and 3-week-old prehypertensive SHR and age-matched genetically normotensive control Wistar-Kyoto (WKY) rats. Blood pressure was similar in WKY and SHR rats at 2 and 3 weeks, of age. Renal inflammation (macrophage and nuclear factor-kappaB) was elevated in SHR at 3 weeks, but not at 2 weeks, of age compared with age-matched WKY rats. Renal oxidative stress (nitrotyrosine, 8-hydroxy-2'-deoxyguanosine and p47phox) was also clearly elevated in 3-week-old SHR compared with age-matched WKY rats. Additionally, NADPH oxidase subunit p47phox was found elevated in 2-week-old SHR compared to age-matched WKY rats. Moreover, antioxidant (N-acetyl-L-cysteine and Tempol) treatment reduced renal inflammation in prehypertensive SHR. We therefore conclude that the oxidative stress appears before inflammation as a primary abnormality in the kidney in prehypertensive SHR.
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Biswas et al. (2007) studied Prehypertension in spontaneously hypertensive rats. Antioxidant (N-acetyl-L-cysteine and Tempol) treatment / Observation vs. WKY rats / No treatment was evaluated on Renal inflammation and oxidative stress. In prehypertensive spontaneously hypertensive rats, renal oxidative stress appears before inflammation as a primary abnormality, and antioxidant treatment reduces renal inflammation.
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