Key result
TAVR cuts in-hospital mortality ~47% vs. SAVR in AS patients with advanced CKD.
Why the study?
The comparative benefits of transcatheter and surgical aortic valve replacement remained controversial for aortic stenosis patients with advanced chronic kidney disease (stage 3-5).
Does transcatheter aortic valve replacement reduce in-hospital mortality and complications compared to surgical aortic valve replacement in aortic stenosis patients with advanced chronic kidney disease?
Meta-Analysis
Does transcatheter aortic valve replacement reduce in-hospital mortality and complications compared to surgical aortic valve replacement in aortic stenosis patients with advanced chronic kidney disease?
Effect estimate: OR 0.53 (95% CI 0.36-0.78)
p-value: p=0.001
TAVR is associated with lower in-hospital mortality and fewer postoperative complications compared to SAVR in patients with aortic stenosis and advanced chronic kidney disease.
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May favor TAVR selection in advanced CKD; extends observational meta-analyses but leaves open randomized confirmation.
Wei et al. (2021) conducted a meta-analysis in Aortic stenosis with advanced chronic kidney disease. Transcatheter aortic valve replacement (TAVR) vs. Surgical aortic valve replacement (SAVR) was evaluated on In-hospital mortality (OR 0.53, 95% CI 0.36-0.78, p=0.001). Transcatheter aortic valve replacement had a lower risk of in-hospital mortality compared to surgical replacement (OR 0.53; 95% CI 0.36-0.78; P=0.001) in AS patients with advanced CKD.
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