January 1, 1999Cellular Physiology and Biochemistry
Cardiac Ultrarapid Delayed Rectifiers
Key result
The ultrarapid delayed rectifier current I(Kur) exhibits distinct molecular bases across species and tissues, representing a potential target for new antiarrhythmic drug development.
Population
Cardiac tissues expressing ultrarapid delayed rectifier currents (I) across various species.
Design
Review
Authors
Discussion
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Implication
Species-specific I(Kur) bases may limit cross-species translation; leaves open selective human atrial antiarrhythmic targeting.
Structured PICO
P
Population
Cardiac tissues expressing ultrarapid delayed rectifier currents (I(Kur)) across various species (e.g., rat atrium, mouse ventricle, human atrium, dog atrium).
This review highlights the molecular diversity of cardiac ultrarapid delayed rectifier currents (I(Kur)) and their potential as targets for novel antiarrhythmic therapies.
Cite This Study
Nattel et al. (1999) conducted a review in Cardiac arrhythmias. I(Kur) channels was evaluated. The ultrarapid delayed rectifier current I(Kur) exhibits distinct molecular bases across species and tissues, representing a potential target for new antiarrhythmic drug development.