Key result
Extracellular application of polyunsaturated fatty acids, such as arachidonic acid and docosahexaenoic acid, produces a direct open channel block of the major voltage-dependent K+ channel (Kv1.5).
Why the study?
Does extracellular application of polyunsaturated fatty acids inhibit Kv1.5 channel activity in cultured cardiomyocytes?
Population
Cloned Kv1.5 channels in cardiac cells, and cultured mouse and rat cardiomyocytes
Comparison
Extracellular application of polyunsaturated… vs Intracellular application via patch pipette
Design
Preclinical
Authors
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May modulate cardiac excitability in models; hypothesis-generating for antiarrhythmic mechanisms, not yet for clinical use.
Does extracellular application of polyunsaturated fatty acids inhibit Kv1.5 channel activity in cultured cardiomyocytes?
Polyunsaturated fatty acids block the major cardiac delayed-rectifier K+ channel (Kv1.5) from the extracellular side, which may contribute to their effects on cardiac function and arrhythmias.
Honoré et al. (1994) studied Cardiac cells / Kv1.5 channel. Polyunsaturated fatty acids (arachidonic acid, docosahexaenoic acid) was evaluated on Kv1.5 channel activity. Extracellular application of polyunsaturated fatty acids, such as arachidonic acid and docosahexaenoic acid, produces a direct open channel block of the major voltage-dependent K+ channel (Kv1.5).
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