Key result
Expression of the long and amino-terminal deleted (Kv1-5 delta 5') isoforms in Xenopus oocytes elicited similar K+ currents, but with drastically decreased efficacy for the short isoform.
Identification and characterization of multiple mRNA isoforms of the mouse cardiac Kv1-5 channel reveals differential functional properties and regulatory interactions.
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Short Kv1.5 isoform efficacy differences warrant no clinical change; leaves open in vivo cardiac roles.
Attali et al. (1993) studied Mouse cardiac Kv1-5 delayed rectifier K+ channel. Expression of Kv1-5 isoforms in Xenopus oocytes was evaluated. Expression of the long and amino-terminal deleted (Kv1-5 delta 5') isoforms in Xenopus oocytes elicited similar K+ currents, but with drastically decreased efficacy for the short isoform.
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