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September 1, 1997Journal of Biological ChemistryOpen Access

Suppression of Slow Delayed Rectifier Current by a Truncated Isoform of KvLQT1 Cloned from Normal Human Heart

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Population

Xenopus oocytes and normal human heart tissue

Comparison

Expression of a truncated isoform of KvLQT1 vs Expression of full-length KvLQT1 or human IsK…

Design

Preclinical

Authors

MJMin JiangElectrophysiologyJTJulie Tseng-CrankEpigen Biosciences (United States)GTGea‐Ny TsengVirginia Commonwealth University

Discussion

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Implication

tKvLQT1 may modulate IKs in experimental models; leaves open its role in human repolarization disorders pending further study.

Structured PICO

P
Population
Xenopus oocytes and normal human heart tissue
I
Intervention
Expression of a truncated isoform of KvLQT1 (tKvLQT1)
C
Comparator
Expression of full-length KvLQT1 or human IsK clone (hIsK) alone
O
Outcome
Electrophysiological function and current suppression (KvLQT1 current and slow delayed rectifier current)surrogate

A truncated isoform of KvLQT1 (tKvLQT1) cloned from the human heart acts as a dominant negative regulator, suppressing the slow delayed rectifier current (IKs).

Cite This Study

Jiang et al. (1997) studied this question.

synapsesocial.com/papers/6a81604fb06901c4fb22dd5chttps://doi.org/10.1074/jbc.272.39.24109
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Also Consider

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  1. 1Role of the Kv4.3 K+Channel in Ventricular Muscle1996 · 437 citations
  2. 2Cloning of a Membrane Protein That Induces a Slow Voltage-Gated Potassium Current1988 · 523 citations
  3. 3Functional role of the NH2-terminal cytoplasmic domain of a mammalian A-type K channel.1993 · 55 citations
  4. 4Drug‐Induced Afterdepolarizations and Triggered Activity Occur in a Discrete Subpopulation of Ventricular Muscle Cells (M Cells) in the Canine Heart:1993 · 108 citations
  5. 5KVLQT1 mutations in three families with familial or sporadic long QT syndrome1996 · 81 citations