The study identifies the RBKV1.5 channel in rabbit heart and demonstrates that its delayed rectifier current is converted to a rapidly inactivating current by a beta subunit.
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No immediate clinical implications from rabbit data; leaves open beta-subunit effects on human Kv1.5.
We have isolated a cDNA coding for a delayed rectifier K+ channel (RBKV1.5) from rabbit heart. The amino acid sequence of RBKV1.5 displays a homology to that of other K+ channels of Kv1.5 class. Overall amino acid identity between RBKV1.5 channel and Kv1.5 channel of other species is about 85%. RNA blot analysis revealed the expression of the primary transcript in various rabbit tissues, at the highest level in both the atrium and ventricle. When expressed in Xenopus oocytes, RBKV1.5 current showed a delayed rectifier type characteristics, which was converted to rapidly inactivating currents upon coexpression with a beta subunit.
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Sasaki et al. (1995) studied this question.
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