Key result
Heteromultimeric Kv channel complexes composed of Kv1.2, Kv1.5, and Kvbeta1.2 subunits form the 4-aminopyridine-sensitive voltage-gated K+ channels in vascular smooth muscle.
This study identifies the specific molecular subunits (Kv1.2, Kv1.5, and Kvbeta1.2) that form heteromultimeric voltage-gated potassium channels in vascular smooth muscle.
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No immediate clinical implications from this animal study; leaves open targeting these Kv subunits in vascular disease.
Thorneloe et al. (2001) studied Vascular smooth muscle physiology. Heteromultimeric Kv channel complexes composed of Kv1.2, Kv1.5, and Kvbeta1.2 subunits form the 4-aminopyridine-sensitive voltage-gated K+ channels in vascular smooth muscle.
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