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May 1, 1996Journal of Biological ChemistryOpen Access

Expression and Function of Voltage-dependent Potassium Channel Genes in Human Airway Smooth Muscle

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Population

Human airway smooth muscle cells and tissue

Design

Preclinical

Authors

SASarvesh AddaMerck & Co., Inc., Rahway, NJ, USA (United States)BFBernd K. FleischmannElectrophysiologyBFBruce D. FreedmanUniversity of Pennsylvania

Discussion

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Implication

Kv1.5 may regulate airway myocyte tone; leaves open therapeutic targeting pending human validation.

Structured PICO

P
Population
Human airway smooth muscle cells and tissue
I
Intervention
Potassium channel blockers (charybdotoxin, 4-aminopyridine, dendrotoxin, glybenclamide)
O
Outcome
Expression of voltage-dependent potassium channel currents and mRNAs, and changes in resting tensionsurrogate

Human airway smooth muscle cells express Kv1.1, Kv1.2, and Kv1.5, with Kv1.5 appearing to regulate basal tone.

Cite This Study

Adda et al. (1996) studied this question.

synapsesocial.com/papers/6a70dd12e5469ee92be189edhttps://doi.org/10.1074/jbc.271.22.13239
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Control of resting membrane potential by delayed rectifier potassium currents in ferret airway smooth muscle cells.1993 · 86 citations
  2. 2Role of Potassium Channels in Bronchodilator Responses in Human Airways1992 · 145 citations
  3. 3Calcium‐activated potassium channels in single smooth muscle cells of rabbit jejunum and guinea‐pig mesenteric artery.1986 · 303 citations
  4. 4Hyperpolarizing Vasodilators Activate ATP-sensitive K + Channels in Arterial Smooth Muscle1989 · 1,197 citations
  5. 5The α-Dendrotoxin Footprint on a Mammalian Potassium Channel1995 · 63 citations