Key result
Expression of rabbit portal vein Kv1.5 in mammalian cells showed identical activation kinetics to native KDR current, but differences in inactivation suggest native channels are not homomultimers.
Kv1.5 alpha-subunits are a component of native KDR channels in vascular smooth muscle, but differences in inactivation kinetics suggest the native current likely involves a more complex heteromultimeric structure.
No takes yet. Share an insight, caveat, or question.
Kv1.5 contributes to rabbit vascular KDR; leaves open heteromultimeric native channel composition and should not guide human therapy.
Clément‐Chomienne et al. (1999) studied Vascular smooth muscle cells. Cloning and expression of rabbit portal vein Kv1.5 vs. Native delayed rectifier K+ (KDR) current was evaluated on Kinetics and voltage dependence of activation and inactivation. Expression of rabbit portal vein Kv1.5 in mammalian cells showed identical activation kinetics to native KDR current, but differences in inactivation suggest native channels are not homomultimers.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: