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November 1, 1994AJP Cell Physiology

Cloning and characterization of a Kv1.5 delayed rectifier K+ channel from vascular and visceral smooth muscles

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Population

Canine colonic smooth muscle and oocytes

Design

Preclinical

Authors

KOKen OverturfAgricultural Research ServiceSRScott N. RussellUniversity of Nevada, RenoACA. CarlUniversity of Nevada, Reno

Discussion

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Implication

Should not yet inform clinical decisions on vascular tone; leaves open cKv1.5 role in human smooth muscle electrophysiology.

Structured PICO

P
Population
Canine colonic smooth muscle and oocytes
I
Intervention
Cloning and functional expression of cKv1.5 K+ channel
O
Outcome
Channel characteristics including amino acid sequence, functional expression, single channel analysis, and tissue distribution

The cKv1.5 channel represents a distinct isoform of the Kv1.5 class and likely contributes to the delayed rectifier current in both vascular and visceral smooth muscles.

Cite This Study

Overturf et al. (1994) studied this question.

synapsesocial.com/papers/6a77df31137c7dcc81be22c5https://doi.org/10.1152/ajpcell.1994.267.5.c1231
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Molecular cloning and characterization of two voltage‐gated K + channel cDNAs from human ventricle1991 · 248 citations
  2. 2Ionic currents in single smooth muscle cells of the canine renal artery.1992 · 80 citations
  3. 3ACTIONS OF 4‐AMINOPYRIDINE ON VASCULAR SMOOTH MUSCLE TISSUES OF THE GUINEA‐PIG1980 · 99 citations
  4. 4Cloning and expression of a Kv1.2 class delayed rectifier K+ channel from canine colonic smooth muscle.1993 · 80 citations
  5. 5Delayed rectifier potassium channels in canine and porcine airway smooth muscle cells.1992 · 89 citations