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January 1, 1980British Journal of PharmacologyOpen Access

Actions of 4‐aminopyridine on Vascular Smooth Muscle Tissues of the Guinea‐pig

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Population

Smooth muscle cells of the guinea-pig pulmonary artery and portal vein

Design

Preclinical

Authors

YHYusuke HaraNational Institute of Information and Communications TechnologyKKKenji KitamuraUniversity of FloridaHKHirosi KuriyamaSeinan Jo Gakuin University

Discussion

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Implication

No direct clinical implications; extends K-conductance observations to guinea-pig vascular smooth muscle.

Structured PICO

P
Population
Smooth muscle cells of the guinea-pig pulmonary artery and portal vein
I
Intervention
4-aminopyridine (4-AP) and procaine
O
Outcome
Membrane and contractile propertiessurrogate

4-AP and procaine suppress K-conductance in guinea-pig vascular smooth muscle, with 4-AP additionally increasing noradrenaline release from nerve terminals.

Cite This Study

Hara et al. (1980) studied this question.

synapsesocial.com/papers/6a197ee6c05413006f586b50https://doi.org/10.1111/j.1476-5381.1980.tb10704.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Relationship between Noradrenaline-Induced Depolarization and Contraction in Vascular Smooth Muscle2008 · 45 citations
  2. 2Mechanism of slow discharges of sheep carotid artery.1978 · 16 citations
  3. 3ON THE ROLES OF CALCIUM ION DURING POTASSIUM INDUCED CONTRACTURE IN THE SMOOTH MUSCLE CELLS OF THE RABBIT MAIN PULMONARY ARTERY1977 · 31 citations
  4. 4Electrical property and chemical sensitivity of vascular smooth muscles in normotensive and spontaneously hypersensitive rats.1978 · 41 citations
  5. 5Effects of tetraethylammonium chloride on the membrane activity of guinea‐pig stomach smooth muscle1970 · 81 citations