Key result
Human Kv4.3 short isoform shows a 10 mV positive inactivation shift versus the long isoform.
Population
Xenopus oocytes expressing human Kv4.3 (hKv4.3) potassium channel isoforms (long and short)
Comparison
Expression of hKv4.3 short isoform vs Expression of hKv4.3 long isoform (full length)
Design
Preclinical
Authors
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May refine models of cardiac and neuronal repolarization; leaves open whether isoform variation contributes to human disease.
Identifies two isoforms of the human Kv4.3 potassium channel with distinct inactivation properties, contributing to the understanding of cardiac and brain electrophysiology.
Dilks et al. (1999) studied this question. hKv4.3 long and short isoforms was evaluated on Electrophysiological properties (inactivation curve and window current). Cloning and expression of two human Kv4.3 potassium channel isoforms revealed the short isoform has a 10 mV positive shift in its inactivation curve relative to the long isoform.
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