January 1, 1999Cardiovascular Research

Functional expression of an inactivating potassium channel (Kv4.3) in a mammalian cell line

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Population

Mammalian cell line (Ltk- cells) expressing Kv4.3 channels

Design

Preclinical

Authors

LFLaura FranquezaUniversidad Complutense de Madrid

Discussion

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Implication

Validates Kv4.3-Ltk- cells as ITO model; extends molecular tools while leaving clinical translation open.

Structured PICO

Population

Mammalian cell line (Ltk- cells) expressing Kv4.3 channels

Intervention

Whole-cell voltage clamp technique and bupivacaine block

Outcome

Electrophysiological properties including activation, inactivation, recovery, and bupivacaine blocksurrogate

Kv4.3 channels expressed in Ltk- cells exhibit a functional profile closely corresponding to rat ITO, supporting their use as a model for studying cardiac transient outward potassium currents.

Cite This Study

Laura Franqueza (1999) studied this question.

synapsesocial.com/papers/6a7e4648567bd3ec6fb7b0cf https://doi.org/10.1016/s0008-6363(98)00220-x

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Functional expression of an inactivating potassium channel (Kv4.3) in a mammalian cell line

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Functional expression of an inactivating potassium channel (Kv4.3) in a mammalian cell line

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider