Key result
Cloning of Kv4.3 revealed it generates an A-type K+ current in Xenopus oocytes and displays complementary expression to Kv4.2 in the rat heart and brain.
Population
Xenopus oocytes and adult rat brain and heart tissues
Comparison
Injection of Kv4.3 transcripts vs Kv4.2 and Kv4.1 mRNAs, or no coinjection
Design
Preclinical
Authors
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No immediate clinical implications; extends molecular basis of A-type K+ currents and leaves functional roles in heart and brain open.
The cloning of Kv4.3 reveals a novel component of A-type K+ channels with distinct expression patterns in the brain and heart, helping explain the diversity of these channels.
Serôdio et al. (1996) studied this question. Kv4.3 cloning and expression vs. Kv4.1 and Kv4.2 was evaluated on A-type K+ current characteristics and expression patterns. Cloning of Kv4.3 revealed it generates an A-type K+ current in Xenopus oocytes and displays complementary expression to Kv4.2 in the rat heart and brain.
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