December 1, 1998Journal of Biological ChemistryOpen Access

Coexpression of the KCNA3BGene Product with Kv1.5 Leads to a Novel A-type Potassium Channel

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Population

Chinese hamster ovary cells and human brain tissue (for mRNA expression analysis)

Design

Preclinical

Authors

TLThorsten LeicherUniversität Hamburg RBRobert BähringElectrophysiology DIDirk IsbrandtGerman Center for Neurodegenerative Diseases

Discussion

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Implication

Identifies a novel Kv1.5/Kvbeta3.1 interaction generating A-type currents; leaves open physiological role in native cardiac myocytes.

Structured PICO

Population

Chinese hamster ovary cells and human brain tissue (for mRNA expression analysis)

Intervention

Heterologous coexpression of human Kv1.5 and Kvbeta3.1 subunits

Outcome

Electrophysiological properties (outward currents upon depolarization)surrogate

The cloning and coexpression of the human Kvbeta3.1 subunit with Kv1.5 reveals a novel mechanism for generating fast-inactivating A-type potassium currents.

Cite This Study

Leicher et al. (1998) studied this question.

synapsesocial.com/papers/6a8a58f35246293882fd83ec https://doi.org/10.1074/jbc.273.52.35095

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Coexpression of the KCNA3BGene Product with Kv1.5 Leads to a Novel A-type Potassium Channel

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Coexpression of the KCNA3BGene Product with Kv1.5 Leads to a Novel A-type Potassium Channel

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider