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March 1, 1995Journal of Biological ChemistryOpen Access

A Novel β Subunit Increases Rate of Inactivation of Specific Voltage-gated Potassium Channel α Subunits

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Population

In vitro expression system (implied Xenopus oocytes) for K+ channel subunits

Comparison

Co-expression of novel Kv beta 3 subunit with K+… vs Expression of K+ channel alpha subunits alone

Design

Preclinical

Authors

MMMichael J. MoralesUniversity of IdahoRCRobert C. CastellinoMerck & Co., Inc., Rahway, NJ, USA (United States)ACAnne L. CrewsNorth Carolina State University

Discussion

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Implication

May modulate cardiac repolarization; leaves open its role in human arrhythmias.

Structured PICO

P
Population
In vitro expression system (implied Xenopus oocytes) for K+ channel subunits
I
Intervention
Co-expression of novel Kv beta 3 subunit with K+ channel alpha subunits (Kv1.4, Shaker B, Kv1.1)
C
Comparator
Expression of K+ channel alpha subunits alone
O
Outcome
Rate of inactivation of K+ channel alpha subunitssurrogate

The novel voltage-gated K+ channel beta subunit Kv beta 3 is present in the cardiovascular system and selectively modulates the inactivation of specific K+ channel alpha subunits.

Cite This Study

Morales et al. (1995) studied this question.

synapsesocial.com/papers/6a7973b8fb5b6b43000db3ebhttps://doi.org/10.1074/jbc.270.11.6272
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Also Consider

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  1. 1Heteromultimeric assembly of human potassium channels. Molecular basis of a transient outward current?1993 · 174 citations
  2. 2Cardiac Electrophysiology: From Cell to Bedside1991 · 2,392 citations
  3. 3Analysis of cytokine mRNA and DNA: detection and quantitation by competitive polymerase chain reaction.1990 · 1,477 citations
  4. 4Purification and subunit structure of a putative K+-channel protein identified by its binding properties for dendrotoxin I.1988 · 203 citations
  5. 5Interactions of amino terminal domains of Shaker K channels with a pore blocking site studied with synthetic peptides.1993 · 151 citations