Key result
Combined experimental and computational strategy generates an equilibrated model for ~20% of the myosin rod.
Population
Five sections of coiled-coil covering 164 amino acid residues constituting 20% of light meromyosin from…
Design
Preclinical
Authors
Loading...
Strategy enables partial myosin rod modeling; leaves open extension to full contiguous structures for cardiac research.
The study demonstrates a feasible experimental and computational strategy to build a contiguous molecular model for the entire myosin rod, overcoming previous aggregation issues.
Korkmaz et al. (2015) studied Myosin rod structure. Experimental and computational modeling was evaluated on Contiguous model of the myosin rod. An experimental and computational strategy combining overlapping structures and >700 ns simulation successfully generated an equilibrated, contiguous model for 20% of the myosin rod.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: