Key result
Clenbuterol administration in rats resulted in muscle fibre hypertrophy and a shift towards faster myosin heavy chain isoforms, including de novo expression of type IIx MHC.
Clenbuterol induces muscle fibre hypertrophy and a shift towards faster myosin heavy chain isoforms in rat soleus muscle.
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Clenbuterol effects on rat muscle should not guide human use; leaves open cardiac remodeling questions.
Oishi et al. (2002) studied Muscle fibre hypertrophy and myosin heavy chain isoform composition (n=20). Clenbuterol vs. Control was evaluated on Phenotypic response at the single fibre level (MHC isoform composition). Clenbuterol administration in rats resulted in muscle fibre hypertrophy and a shift towards faster myosin heavy chain isoforms, including de novo expression of type IIx MHC.
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