Key result
Hind limb immobilisation for 2 days in adult male rats altered myogenic regulatory factor transcripts in a muscle-specific manner, with myogenin elevated in stretched plantaris and MRF4 in soleus.
Myogenic regulatory factor transcripts exhibit muscle-specific responses to passive stretch and disuse atrophy in adult rats.
Should not change clinical disuse management; hypothesis-generating for muscle-specific MRF responses in human atrophy.
Levels of myogenic regulatory factor (MRF) transcripts are altered in a muscle-specific manner in response to hind limb immobilisation of adult male rats, for a 2 day period, in either a lengthened or shortened position which result in passive stretch or disuse atrophy respectively. Myogenin transcript levels were dramatically elevated in the stretched plantaris but not soleus, whereas the MRF4 transcript was significantly elevated in soleus but not plantaris. Levels of myogenin mRNA were unaffected by disuse in either muscle and MRF4 was markedly lower in plantaris in response to disuse.
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Loughna et al. (1996) studied Disuse atrophy and passive stretch. Hind limb immobilisation in lengthened or shortened position was evaluated on Levels of myogenic regulatory factor (MRF) transcripts (myogenin and MRF4). Hind limb immobilisation for 2 days in adult male rats altered myogenic regulatory factor transcripts in a muscle-specific manner, with myogenin elevated in stretched plantaris and MRF4 in soleus.
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