Key result
Sympathetic nerve antibodies were significantly less prevalent in Type 1 diabetic patients with autonomic neuropathy than in those without (11% vs 47%, P<0.002).
Why the study?
Are autonomic nerve antibodies associated with autonomic nerve function in patients with Type 1 and Type 2 diabetes?
Observational (n=112)
Are autonomic nerve antibodies associated with autonomic nerve function in patients with Type 1 and Type 2 diabetes?
Absolute Event Rate: 11% vs 47%
p-value: p=<0.002
Autonomic nerve antibodies show different patterns of association with autonomic neuropathy in Type 1 versus Type 2 diabetes.
Antibodies appear inversely associated with neuropathy in Type 1 diabetes; leaves open causal role and Type 2 differences.
Complement-fixing adrenal medulla (CF-ADM), sympathetic ganglion (CF-SG), and vagal (CF-V) nerve antibodies were determined in diabetic patients. Among 74 patients with Type 1 diabetes, CF-ADM was detected in 7 (10%) cases, CF-SG in 14 (19%) cases, and CF-V in 8 (11%) cases. Among 38 patients with Type 2 diabetes, CF-ADM was detected in 5 (13%) cases, CF-SG in 4 (11%) cases, and CF-V in 6 (16%) cases. There were associations between autonomic nerve antibodies and autonomic nerve function. CF-ADM and/or CF-SG were significantly (P less than 0.002) less prevalent in Type 1 diabetic patients with autonomic neuropathy than in those without [5/44 (11%) vs. 14/30 (47%)] and, in agreement with this, the brake index, a sign of parasympathetic and sympathetic autonomic nerve function, was significantly (P less than 0.005) higher (more normal) in these patients (-0.56 +/- 0.13 vs. -1.04 +/- 0.12). In Type 2 diabetic patients, the E/I ratio, an index of parasympathetic nerve function, was significantly (P less than 0.03) lower (more abnormal) in those with CF-V than in those without (-1.81 +/- 0.17 vs. -1.20 +/- 0.11). In conclusion, the frequency of sympathetic nerve antibodies was decreased in Type 1 diabetic patients with autonomic neuropathy, while in Type 2 diabetic patients parasympathetic nerve antibodies were related to severe parasympathetic neuropathy.
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SUNDKVTST et al. (1991) conducted an observational in Type 1 and Type 2 diabetes (n=112). Autonomic nerve antibodies (CF-ADM, CF-SG, CF-V) vs. Absence of autonomic neuropathy / Absence of antibodies was evaluated on Prevalence of CF-ADM and/or CF-SG antibodies in Type 1 diabetic patients with vs without autonomic neuropathy (p=<0.002). Sympathetic nerve antibodies were significantly less prevalent in Type 1 diabetic patients with autonomic neuropathy than in those without (11% vs 47%, P<0.002).
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