Key result
Right ventroposterolateral nucleus gamma oscillations strongly correlate with blood pressure variability, explaining ~79% of variance.
Why the study?
Elevated blood pressure variability is a cardiovascular risk factor often resistant to pharmacotherapies, prompting evaluation of local field potentials to potentially guide deep brain stimulation devices.
Do local field potentials (LFPs) correlate with blood pressure variability (BPV) in chronic pain patients?
Observational (n=22)
No
Do local field potentials (LFPs) correlate with blood pressure variability (BPV) in chronic pain patients?
Local field potential gamma oscillations in the right ventroposterolateral nucleus correlate strongly with blood pressure variability, suggesting potential for closed-loop deep brain stimulation therapies.
Answers are grounded in this paper and cite their sources.
Should not yet guide DBS programming; leaves open RVPL gamma oscillations as biomarkers for closed-loop BPV control.
The intention was to associate blood pressure (BP) variability (BPV) measurements to Local field potentials (LFPs). Thus, assessing how LFPs can co-vary with BPV to permit implantable brain devices (via LFPs) to control output. Elevated BPV is a considerable cardiovascular disease risk factor. Often patients are resistant to pharmacotherapies. An alternative treatment is Deep Brain Stimulation (DBS). Mathematical techniques based on nonlinear dynamics assessed their correlation of BPV chaotic global metrics to LFPs. Chaos Forward Parameter (CFP6) was computed for LFPs, at three electrode depths in the mid-brain and sensory thalamus. Mean, root mean square of the successive differences (RMSSD) and the chaotic global metrics (CFP1 to CFP7) were computed for the BP signal. The right ventroposterolateral (RVPL) nucleus provided a substantial correlation via CFP6 for BP with R-squared up to approximately 79% by means of LFP gamma oscillations. Investigation of BPV via LFPs as a proxy marker might allow therapies to be attuned in a closed-loop system. Whilst all patients were chronic pain patients the chaotic global relationship should be unperturbed. LFPs correlation does not unconditionally predict its causation. There is no certainty DBS in these locations would be therapeutic but can be used as an assessment tool.
No takes yet. Share an insight, caveat, or question.
Garner et al. (2023) conducted an observational in Chronic neuropathic pain (n=22). Local field potential (LFP) monitoring via DBS electrodes was evaluated on Correlation (R-squared) between LFP gamma oscillations and blood pressure variability (CFP6) in the RVPL nucleus (R-squared up to 79%). Local field potential gamma oscillations in the right ventroposterolateral nucleus correlated substantially with blood pressure variability, achieving an R-squared of up to 79%.
Synapse has enriched 10 related papers. Consider them for comparative context: