Key result
MMP1 and MMP3 haplotypes 2G-5A and 1G-6A linked to higher MI risk versus reference 2G-6A.
Why the study?
MMP1 and MMP3 variants had been investigated individually with ischemic heart disease and LV dysfunction, but not as haplotypes.
Are MMP1 and MMP3 haplotypes associated with the occurrence of myocardial infarction and subsequent left ventricular remodeling?
Case-Control (n=608)
Are MMP1 and MMP3 haplotypes associated with the occurrence of myocardial infarction and subsequent left ventricular remodeling?
p-value: p=0.009 and 0.026
MMP1 and MMP3 haplotypes are significantly associated with the occurrence of myocardial infarction, though their impact on subsequent left ventricular remodeling requires further validation.
Haplotypes associated with MI but not remodeling after correction; leaves open clinical utility and requires prospective validation.
BACKGROUND: Myocardial infarction (MI) leads to ischemia and afterward to left ventricular (LV) remodeling. Matrix metalloproteinase-1 (MMP1) and -3 (MMP3) belong to the family of endopeptidases and together they can dissolve most of the components of the extracellular matrix. MMP1 and MMP3 variants have been investigated solely in association with ischemic heart disease and LV dysfunction, but not in haplotype. The aims of this study were to investigate the association of haplotypes inferred from MMP1 rs1799750 (-1607 1G/2G; NC_000011.9:g.102670497del) and MMP3 rs35068180 (-1612 5A/6A; NC_000011.9:g.102715952dup) with MI and their effect on the change in echocardiographic parameters of LV structure and function in patients within 6 months after MI. METHODS: The study included 325 patients with the first MI and 283 healthy controls. Gene variants were detected by PCR-RFLP method. Parameters of LV structure and function were assessed by conventional 2D echocardiography, 3-5 days and 6 months after the first MI, on a subgroup of 160 patients. Haplotype analysis was performed with Thesias software. RESULTS: Haplotypes 2G-5A and 1G-6A were significantly and independently associated with MI compared with the reference haplotype 2G-6A (adjusted, p = 0.009 and p = 0.026, respectively). After Bonferroni correction for multiple testing, MMP1 and MMP3 haplotypes lost their association with the change in LV long diameter and stroke volume within 6 months after MI. CONCLUSION: MMP1 and MMP3 haplotypes are strongly associated with MI. Further studies are needed to validate this result and to examine their association with echocardiographic parameters of LV structure and function after MI.
No takes yet. Share an insight, caveat, or question.
Djurić et al. (2022) conducted a case-control in Myocardial infarction (n=608). MMP1 and MMP3 haplotypes (2G-5A and 1G-6A) vs. Reference haplotype 2G-6A was evaluated on Association with myocardial infarction (p=0.009 and 0.026). MMP1 and MMP3 haplotypes 2G-5A and 1G-6A were significantly associated with myocardial infarction compared with the reference haplotype 2G-6A (p=0.009 and p=0.026, respectively).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: