What is the clinical evidence from this study?

Study design: Review. Population: Cardiac hypertrophy. Intervention: Mechanical stress.

What question did this study set out to answer?

The aim is to explore how mechanical stress influences cardiac myocytes and the cellular responses involved in hypertrophy.

October 1, 1997Annual Review of Physiology

The Cellular and Molecular Response of Cardiac Myocytes to Mechanical Stress

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Key result

Mechanical stretch of cardiac myocytes activates multiple second messenger systems and stimulates rapid secretion of angiotensin II, mediating hypertrophic responses in vitro.

Key Points

The aim is to explore how mechanical stress influences cardiac myocytes and the cellular responses involved in hypertrophy.
Review of literature on mechanical stress impacts on cardiac myocytes.
Analysis of second messenger systems activated by mechanical stimuli.
Discussion on the relationship between mechanical loading and the renin-angiotensin system.
Mechanical stretch activates second messenger pathways similar to growth factor signaling.
Angiotensin II secretion is rapidly stimulated by mechanical stretch in neonatal rat cardiac myocytes.
The review highlights important mechanosensing mechanisms involved in the hypertrophic response.

Structured PICO

Population

Cardiac myocytes (including neonatal rat cardiac myocytes in vitro)

Intervention

Mechanical stress/stretch

Outcome

Cell signaling mechanisms and hypertrophic responses

This review highlights how mechanical stretch in cardiac myocytes activates intracellular signaling and the local renin-angiotensin system to induce hypertrophy.

Discussion

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Implication

Supports local angiotensin II investigation in hypertrophy models; leaves open in vivo and clinical translation.

Cite This Study

Sadoshima et al. (1997) conducted a review in Cardiac hypertrophy. Mechanical stress was evaluated. Mechanical stretch of cardiac myocytes activates multiple second messenger systems and stimulates rapid secretion of angiotensin II, mediating hypertrophic responses in vitro.

synapsesocial.com/papers/6a0dda6be51d8d6d0c09dc41 https://doi.org/10.1146/annurev.physiol.59.1.551

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The Cellular and Molecular Response of Cardiac Myocytes to Mechanical Stress

Key Points

Structured PICO

Discussion

Implication

Cite This Study

The Cellular and Molecular Response of Cardiac Myocytes to Mechanical Stress

Key Points

Structured PICO

Discussion

Implication

Cite This Study

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Also Consider