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May 1, 2004Annals of the New York Academy of Sciences

Mechanotransduction in Cardiac Myocytes

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Population

Cardiac myocytes

Design

Review

Authors

JLJan LammerdingCornell University
Roger D. Kamm
Roger D. KammVascular MedicineRLRichard LeeBroad Institute

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Overview

Stretch-activated pathways may guide anti-remodeling drug development; leaves open whether modulation improves clinical outcomes in heart failure.

Structured PICO

P
Population
Cardiac myocytes

This review highlights the complex mechanotransduction pathways in cardiac myocytes that contribute to pathological hypertrophy and fibrosis.

Cite This Study

Lammerding et al. (2004) studied this question.

synapsesocial.com/papers/6a8810faab77196d53aa69cfhttps://doi.org/10.1196/annals.1302.005
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Stimulus-dependent Subcellular Localization of Activated Protein Kinase C; a Study with Acidic Fibroblast Growth Factor and Transforming Growth Factor- 1 in Cardiac Myocytes1995 · 44 citations
  2. 2Calcium imaging of mechanically induced fluxes in tissue-cultured chick heart: role of stretch-activated ion channels1992 · 238 citations
  3. 3Streptomycin reverses a large stretch induced increase in [Ca2+]i in isolated guinea pig ventricular myocytes1994 · 124 citations
  4. 4Altered Crossbridge Kinetics in the αMHC 403/+ Mouse Model of Familial Hypertrophic Cardiomyopathy1999 · 101 citations
  5. 5Cardiac hypertrophy and failure: lessons learned from genetically engineered mice2001 · 30 citations