Key result
Several biomarkers strongly correlate with microvascular complications in metabolic syndrome.
Why the study?
Metabolic syndrome and diabetes mellitus are closely associated with microvascular complications, requiring the identification of potential biomarkers to facilitate early detection in patients with metabolic syndrome.
Can specific biomarkers facilitate the early detection of microvascular complications in patients with metabolic syndrome?
Can specific biomarkers facilitate the early detection of microvascular complications in patients with metabolic syndrome?
Potential biomarkers may facilitate the early detection and risk assessment of microvascular complications in patients with metabolic syndrome.
May support risk stratification in metabolic syndrome; leaves open prospective validation before any practice change.
Background: Metabolic syndrome is a complex disorder characterized by the coexistence of multiple risk factors, including dysglycemia, hypertension, dyslipidemia, and visceral obesity. Both metabolic syndrome and diabetes mellitus are closely associated with the onset of microvascular complications such as retinopathy, polyneuropathy, and nephropathy. Methods: This narrative review analyzed 137 studies published up to 2025, retrieved from PubMed and Crossref databases. The objective was to identify and evaluate potential biomarkers that could facilitate the early detection of microvascular complications in patients with metabolic syndrome. Results: Several biomarkers demonstrated a strong correlation with microvascular complications in individuals with metabolic syndrome. These findings suggest their potential role in early diagnosis and risk assessment. Conclusions: The identification of reliable biomarkers may enhance early detection and targeted interventions for microvascular complications in metabolic syndrome. Further research is essential to validate these markers and establish their clinical applicability in routine medical practice.
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Nikolova et al. (2025) conducted a review in Metabolic syndrome. Biomarkers was evaluated on Correlation of biomarkers with microvascular complications. A narrative review of 137 studies found that several biomarkers demonstrate a strong correlation with microvascular complications in patients with metabolic syndrome.
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