Key result
Obesity and fasting glucose levels in patients with metabolic syndrome positively correlated with vascular changes in the fundus of the eye (prevalence 72%), whereas HDL-C had a negative correlation.
Observational (n=108)
In patients with metabolic syndrome, obesity and fasting glucose are positively correlated, while HDL-C is negatively correlated, with the intensity of microvascular changes.
Retinal microvascular changes may mark metabolic syndrome severity; cross-sectional data leaves causal roles of obesity and glucose open.
We assessed the influence of metabolic syndrome (MetS) characteristics on vascular complications. The study included 108 patients (72 women and 36 men, age 57.0 ± 8.5 years) with MetS that was diagnosed according to International Diabetes Federation criteria. The prevalence of micro- and macrovascular complications was assessed: vascular changes in the fundus of the eye-72%, ischemic heart disease-54.9%, estimated glomerular filtration rate (eGFR) <90 mL/min-38.9%, diabetic foot-5.55%, and cerebrovascular accident-3.7% of patients. A negative correlation between high-density lipoprotein cholesterol (HDL-C) concentration, creatinine levels, and level of vascular changes in the fundus of the eye was found. Moreover, the level of obesity and fasting glucose level had positive correlation with the intensity of vascular changes in the fundus of the eye. Characteristics of MetS (obesity and fasting glucose level) have high impact on advancing vascular complications in these patients. High level of HDL-C decreases the intensity of vascular changes in patients with MetS.
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Irzmański et al. (2011) conducted an observational in Metabolic syndrome (n=108). Metabolic syndrome characteristics (obesity, fasting glucose, HDL-C) was evaluated on Prevalence of micro- and macrovascular complications and correlation with metabolic syndrome characteristics. Obesity and fasting glucose levels in patients with metabolic syndrome positively correlated with vascular changes in the fundus of the eye (prevalence 72%), whereas HDL-C had a negative correlation.
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