Key result
Preoperative beta-blockers in vascular surgery linked to ~106% higher risk of postoperative delirium.
Why the study?
Does preoperative medication use increase the risk of postoperative delirium in patients aged 18 years and older undergoing major surgery?
Systematic Review
Does preoperative medication use increase the risk of postoperative delirium in patients aged 18 years and older undergoing major surgery?
Effect estimate: OR 2.06 (95% CI 1.18-3.60)
p-value: p=0.011
Preoperative use of certain medications, including psychoactive drugs, beta-blockers, and benzodiazepines, may increase the risk of postoperative delirium, highlighting the need for careful medication review before major surgery.
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May warrant preoperative medication review in major surgery; extends observational associations but leaves causality open.
Kassie et al. (2017) conducted a systematic review in Postoperative delirium. Preoperative medication use (e.g., beta-blockers, benzodiazepines, psychoactive medications) vs. No preoperative use of the specific medication was evaluated on Postoperative delirium (associated with preoperative beta-blocker use in vascular surgery) (OR 2.06, 95% CI 1.18-3.60, p=0.011). Preoperative use of beta-blockers in vascular surgery (OR 2.06) and benzodiazepines prior to orthopedic surgery (RR 2.10) were significantly associated with an increased risk of postoperative delirium.
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