Why the study?
Does exposure to psychoactive medications increase the risk of postoperative delirium in surgical patients?
Population
245 patients from general surgery, orthopedic surgery, and gynecology services at Brigham and Women's…
Comparison
Postoperative exposure to psychoactive… vs Matched controls without delirium, assessed for…
Design
Case-control, Reviewer blinded to the study hypothesis for medication exposure…
Follow-up
postoperative days 2 through 5
Authors
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May warrant caution with meperidine and benzodiazepines postoperatively; hypothesis-generating for delirium prevention trials.
Does exposure to psychoactive medications increase the risk of postoperative delirium in surgical patients?
Postoperative exposure to meperidine and benzodiazepines is significantly associated with an increased risk of developing delirium in surgical patients.
Edward R. Marcantonio (1994) studied this question.
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