Research Progress on the Correlation between Inflammatory Cytokines and Diminished Ovarian Reserve

卵巢储备功能减退(diminished ovarian reserve, DOR)是育龄期女性常见的生殖内分泌疾病，其表现为与年龄、遗传或环境等因素相关的卵子数量和质量下降。长期的慢性炎症会加速身体衰老，从而累及卵巢储备(ovarian reserve, OR)，对女性的生殖健康及心理健康造成负面影响。文章综述了不同炎症因子及相关信号通路与DOR发生发展的研究进展，为寻找DOR的病因及早期临床干预提供新思路。Diminished ovarian reserve (DOR) is a common reproductive endocrine disorder among women of childbearing age, characterized by a decline in the quantity and quality of eggs related to factors such as age, genetics, or environment. Chronic inflammation over a long period can accelerate the aging of the body and thereby affect ovarian reserve (OR), having a negative impact on the reproductive health and mental health of women. This article reviews the research progress on different inflammatory factors and related signaling pathways related to the occurrence and development of DOR, providing new ideas for finding the causes of DOR and conducting early clinical intervention.