Key result
Highest TyG-WC index quartile linked to ~66% greater CAC progression versus the lowest quartile.
Why the study?
The triglyceride glucose index is a reliable marker for insulin resistance, but its association and that of related markers with coronary artery calcification progression required investigation.
Does the TyG-WC index predict coronary artery calcification progression better than other indices of insulin resistance in asymptomatic participants?
Observational (n=1,145)
Does the TyG-WC index predict coronary artery calcification progression better than other indices of insulin resistance in asymptomatic participants?
The TyG-WC index is a superior predictor of coronary artery calcification progression compared to other insulin resistance indices, serving as a potential marker for future coronary atherosclerosis.
TyG-WC index was associated with CAC progression; leaves open its superiority to other insulin resistance indices and clinical utility.
The triglyceride glucose (TyG) index, a product of triglyceride and fasting glucose, is a reliable marker for insulin resistance. We aimed to investigate the association between the TyG-related markers and coronary artery calcification (CAC) progression. We enrolled 1145 asymptomatic participants who underwent repeated CAC score measurements during routine health examinations. Homeostasis model assessment of insulin resistance (HOMA-IR), TyG index, TyG-BMI (body mass index), and TyG-WC (waist circumference) were calculated. Progression of CAC was defined as (1) incident CAC in a CAC-free population, or an (2) increase of ≥2.5 units between the baseline and final square root of the CAC scores in participants with detectable CAC. According to the quartiles of parameters, we stratified the subjects into four groups. The prevalence of progression increased with the TyG-WC quartile (15.0%, 24.1%, 31.0%, and 32.2% for each of the groups; p < 0.001). The multivariate-adjusted odds ratio (95% confidence interval) for CAC score progression was 1.66 (1.01–2.77) when the highest and lowest TyG-WC index quartiles were compared. Furthermore, the predictability of TyG-WC for CAC progression was better than the other indices in terms of the area under the curve. The TyG-WC index predicted CAC progression better than other indices and could be a potential marker of future coronary atherosclerosis.
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Cho et al. (2020) conducted an observational in Coronary artery calcification (n=1,145). TyG-WC index vs. Lowest TyG-WC quartile was evaluated on Coronary artery calcification (CAC) progression (OR 1.66, 95% CI 1.01-2.77, p=< 0.001). The highest quartile of the TyG-WC index was associated with increased coronary artery calcification progression compared to the lowest quartile (OR 1.66; 95% CI 1.01-2.77).
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