Key result
Participants with a TyG-BMI index in the highest tertile were significantly more likely to have coronary artery calcification compared to those in the lowest tertile (OR 1.612).
Why the study?
The relationship between triglyceride glucose (TyG) index and subclinical coronary atherosclerosis measured by coronary artery calcium score (CACS) was not well studied.
Does the Triglyceride glucose (TyG) index predict coronary artery calcification better than other indices of insulin resistance in adults?
Cross-Sectional (n=30,776)
No
Does the Triglyceride glucose (TyG) index predict coronary artery calcification better than other indices of insulin resistance in adults?
Odds Ratio: 1.612 (95% CI 1.465–1.774)
The TyG index and its derivatives are better predictors of subclinical coronary atherosclerosis (measured by CACS) than HOMA-IR in a large screening population.
Purpose: Insulin resistance is one of the most important mechanisms in the development of diabetes, and it is closely related to the presence and severity of coronary heart disease.Triglyceride glucose (TyG) index is a useful marker of insulin resistance; however, few studies have investigated the relationship between TyG and subclinical atherosclerosis.Therefore, we evaluated the association of TyG and subclinical coronary atherosclerosis as measured by coronary artery calcium score (CACS).Methods: Our study included 30,776 participants (mean age of 41 years, 80.4% male) enrolled in a health screening program, in whom CACS were measured.Homeostasis model assessment of insulin resistance (HOMA-IR), TyG index, TyG-body mass index (BMI), and TyG-waist circumference (WC) were subsequently analyzed.Indices were calculated using the following formulae: HOMA-IR = fasting insulin (μU/mL)×fasting plasma glucose (FPG; mmol/L)/22.5;TyG index = Ln [TG (mg/dL)×FPG (mg/dL)/2]; TyG-BMI = TyG index × BMI; and TyG-WC = TyG index × WC.CACS was measured using multidetector computed tomography, and the presence of coronary artery calcification (CAC) was defined by CACS > 0.Results: The prevalence of CAC was 14.4% in the study population.Multivariate logistic regression analysis showed that participants with TyG-BMI in the highest tertile were 1.638 times more likely to have CAC after adjustment for other metabolic parameters compared with participants with TyG-BMI in the lowest tertile (odds ratio, 1.612; 95% confidence interval, 1.465 to 1.774).The receiver operating characteristics curve for prediction of CAC showed that TyG-WC index had a higher area under the curve (AUC= 0.626) than other indices (AUC TyG = 0.617, AUC TyG-BMI = 0.616, AUC HOMA-IR = 0.562).Conclusion: TyG index predicted CAC better than other markers of insulin resistance, and could be a useful marker for predicting subclinical atherosclerosis.
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Kim et al. (2017) conducted a cross-sectional in Subclinical coronary atherosclerosis (n=30,776). TyG-BMI index (highest tertile) vs. TyG-BMI index (lowest tertile) was evaluated on Presence of coronary artery calcification (CACS > 0) (OR 1.612, 95% CI 1.465-1.774). Participants with a TyG-BMI index in the highest tertile were significantly more likely to have coronary artery calcification compared to those in the lowest tertile (OR 1.612).
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