Key result
Higher total cholesterol linked to ~56% lower odds of MI and angina in men.
Why the study?
The best obesity index for myocardial infarction or angina pectoris risk assessment remains controversial, and the association between biochemical indices and these diseases is unclear.
Are obesity and biochemical indices associated with myocardial infarction or angina pectoris in the South Korean population aged ≥ 50 years?
Cross-Sectional (n=22,509)
Are obesity and biochemical indices associated with myocardial infarction or angina pectoris in the South Korean population aged ≥ 50 years?
Effect estimate: OR 0.436 (95% CI 0.384-0.495)
p-value: p=<0.001
In a large South Korean cohort, waist-to-height ratio and waist circumference were significantly associated with myocardial infarction or angina pectoris in men but not women, highlighting sex-specific differences in obesity-related cardiovascular risk.
Findings should not change practice; leaves open sex-specific adiposity roles in MIAP for prospective study.
The best obesity index for myocardial infarction or angina pectoris (MIAP) risk assessment remains controversial. Furthermore, the association between biochemical indices and these diseases is unclear. This study examined associations of obesity and biochemical indices with MIAP in the Korean population. This large-scale cross-sectional study was based on the Korea National Health and Nutrition Survey dataset from 2010 to 2019. A total of 22,509 subjects (9452 men and 13,057 women) aged ≥ 50 years were included. Participants consisted of 21,426 individuals without MIAP (men = 8869, women = 12,557) and 1083 with MIAP (men = 583, women = 500). Binary logistic regression was performed to examine the association of MIAP with obesity and biochemical indices. The prevalence of MIAP in Korean adults aged ≥ 50 years was 4.81% (6.57% among men, 3.98% among women). MIAP was more strongly associated with total cholesterol than other variables in men (adjusted OR = 0.436 [0.384-0.495], adjusted p < 0.001) and women (adjusted OR = 0.541 [0.475-0.618], adjusted p < 0.001). The waist-to-height ratio (adjusted OR = 1.325 [1.082-1.623], adjusted p = 0.007) and waist circumference (adjusted OR = 1.290 [1.072-1.553], adjusted p = 0.007) showed a significant association with MIAP in men, with no association between obesity indices and MIAP in women after adjustment. The association between biochemical indices and MIAP differed slightly according to sex. Only total cholesterol, creatinine, and platelets were associated with MIAP in both men and women.
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Hee et al. (2022) conducted a cross-sectional in Myocardial infarction and angina pectoris (MIAP) (n=22,509). Total cholesterol was evaluated on Association of total cholesterol with myocardial infarction and angina pectoris in men (OR 0.436, 95% CI 0.384-0.495, p=<0.001). Total cholesterol was strongly inversely associated with myocardial infarction and angina pectoris in both men (OR 0.436) and women (OR 0.541), while waist-to-height ratio was associated with MIAP only in men.
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