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May 17, 2022European Journal of Preventive Cardiology

Age-dependent associations of body mass index with myocardial infarction, heart failure, and mortality in over 9 million Koreans

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Why the study?

While obesity is a known cardiovascular risk factor, it was unclear whether age modifies the association between body mass index and cardiovascular outcomes.

Does the association between body mass index and cardiovascular outcomes (MI, HF, mortality) vary by age in a Korean population without prior cardiovascular disease?

Population

9 278 433 Koreans without prior cardiovascular disease

Comparison

BMI categories vs optimal normal weight (18.5-22.9 kg/m2) across age groups

Design

Population-based cohort study

Follow-up

8.2 years

Authors

HKHyung‐Kwan KimCardiac ImagingKHKyung Do HanSoongsil UniversityKLKyu na LeeSoongsil University

Discussion

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Implication

Age modifies BMI-outcome associations in this primary-prevention cohort; leaves open age-specific targets pending prospective trials.

Structured PICO

Does the association between body mass index and cardiovascular outcomes (MI, HF, mortality) vary by age in a Korean population without prior cardiovascular disease?

P
Population
9,278,433 Koreans without prior cardiovascular disease, categorized into young (20-39 years), middle-aged (40-64 years), and elderly (≥65 years) groups.
I
Intervention
Body mass index (BMI) categories
C
Comparator
Optimal normal weight (18.5-22.9 kg/m2)
O
Outcome
Incidence of myocardial infarction (MI), heart failure (HF), and all-cause death over 8.2 years follow-uphard clinical

The relationship between BMI and cardiovascular risk is age-dependent, suggesting weight loss is beneficial for younger overweight individuals, while mild overweight may be protective in the elderly.

Cite This Study

Kim et al. (2022) studied this question.

synapsesocial.com/papers/6a7faec5138fa0ec199feadbhttps://doi.org/10.1093/eurjpc/zwac094

Topics

Heart failureHFrEF treatment
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Effect of Age on the Association between Body-Mass Index and Mortality1998 · 1,627 citations
  2. 2Obesity and the Risk of Heart Failure2002 · 3,045 citations
  3. 3Association of Overweight With Increased Risk of Coronary Heart Disease Partly Independent of Blood Pressure and Cholesterol Levels<subtitle>A Meta-analysis of 21 Cohort Studies Including More Than 300 000 Persons</subtitle>2007 · 640 citations
  4. 4Validation of diagnostic codes of major clinical outcomes in a National Health Insurance database2019 · 168 citations
  5. 5Age Changes in Body Composition Revealed by Computed Tomography1983 · 463 citations